Solucionario Sistemas De Comunicaciones Electronicas 4ta Edicion Wayne Tomasi.856 solucionario sistemas de comunicaciones 4ta edicion wayne tomasi.856 【pdf】.
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libros para libros espaciales Solucionario Sistemas De Comunicaciones Electronicas 4ta Edicion Wayne Tomasi.856 .Design, synthesis and biological evaluation of alkenyl substituted cyclic carbamates as potent and selective GABA receptor antagonists.
The alkenyl substituted cyclic carbamates 1-6 were synthesized from the corresponding amides 8-12 by reacting with appropriate alpha-halogen substituted allyl alcohols in the presence of K(2)CO(3) under microwave irradiation in a short time. The inhibitory effect of the synthesized compounds on the chloride currents induced by GABA in rat dorsal root ganglion cells was assayed by the whole cell patch-clamp technique. Several compounds exhibited significant GABA-A receptor antagonistic activity. The antagonist activity of the tested compounds was strongly dependent on the substituents. The activities of alkenyl substituted cyclic carbamates were well correlated with their estimated lipophilicity. Among the synthesized compounds, 12 was found to be the most potent with IC(50) = 11 microM. ac619d1d87
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